JAK inhibition for Dupuytren disease?
نویسندگان
چکیده
منابع مشابه
JAK-STAT pathway and JAK inhibitors: a primer for dermatologists
Background: All cellular events depend upon the DNA synthesis and gene expression involving complex interplay between ligands such as interleukins and interferons, with various cell membrane receptors. These ligand-receptors interactions transmit signals within the cell via numerous signal transduction pathways to affect gene expression. Janus kinase/signal transducer and activator of transcrip...
متن کاملDupuytren disease: Anatomy, pathology, presentation, and treatment.
The disorder called Dupuytren's disease has been recognized for approximately 400 years. Its presentation, although seemingly rather constant, is actually extremely variable, depending on which structures are involved. A thorough knowledge of palmar fascial anatomy is essential to the understanding of Dupuytren's disease.
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PURPOSE Dupuytren's disease is a common fibroproliferative condition of the hand characterized by fibrotic lesions (nodules and cords), leading to disability through progressive digital contracture. Although the etiology of the disease is poorly understood, recent evidence suggests that abnormal matrix metalloproteinase (MMP) activity may play a role in cell-mediated collagen contraction and ti...
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NK cells are innate immune effector cells recognizing and killing virus-infected or malignant cells [1].NK cell function is tightly regulated by a complex balance between various activating and inhibitory NK cell receptors. In addition, several cytokines (IL-2, IL-12, IL-15 and IL-18) mediated via the JAK/STAT pathway are critical for NK cell development and activation. Thus it is tempting to s...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2020
ISSN: 1759-4790,1759-4804
DOI: 10.1038/s41584-020-0485-2